دورية أكاديمية
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
| العنوان: | Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. |
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| المؤلفون: | Baocai Wang, Benedikt Kaufmann, Carolin Mogler, Suyang Zhong, Yuhan Yin, Zhangjun Cheng, Roland M Schmid, Helmut Friess, Norbert Hüser, Guido von Figura, Daniel Hartmann |
| المصدر: | PLoS ONE, Vol 18, Iss 11, p e0294257 (2023) |
| بيانات النشر: | Public Library of Science (PLoS), 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | IntroductionHepatic fibrosis is a progressive pathological process involving the exhaustion of hepatocellular regenerative capacity and ultimately leading to the development of cirrhosis and even hepatocellular carcinoma. Brg1, the core subunit of the SWI/SNF chromatin-remodeling complex, was recently identified as important for liver regeneration. This study investigates the role of Brg1 in hepatic fibrosis development.MethodsHepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis. Afterwards, liver fibrosis and liver damage were assessed.ResultsBrg1 expression was significantly increased in the fibrotic liver tissue of wild-type mice, as compared to that of untreated wild-type mice. The livers of the Brg1 knockout animals showed reduced liver inflammation, extracellular matrix accumulation, and liver fibrosis. TNF-α and NF-κB-mediated inflammatory response was reduced in Brg1 knockout animals.ConclusionBrg1 promotes the progression of liver fibrosis in mice and may therefore be used as a potential therapeutic target for treating patients with liver fibrosis due to chronic injury. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294257&type=printable; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0294257&type=printable |
| DOI: | 10.1371/journal.pone.0294257 |
| URL الوصول: | https://doaj.org/article/888e4bdaf26d4e89930db833f3af5847 |
| رقم الأكسشن: | edsdoj.888e4bdaf26d4e89930db833f3af5847 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0294257&type=printable |