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Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer

التفاصيل البيبلوغرافية
العنوان: Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer
المؤلفون: Ji-Yeon Kim, Sabin Park, Eun Yoon Cho, Jeong Eon Lee, Hae Hyun Jung, Byung Joo Chae, Seok Won Kim, Seok Jin Nam, Soo Youn Cho, Yeon Hee Park, Jin Seok Ahn, Semin Lee, Young-Hyuck Im
المصدر: Experimental and Molecular Medicine, Vol 55, Iss 7, Pp 1451-1461 (2023)
بيانات النشر: Nature Publishing Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Biochemistry
مصطلحات موضوعية: Medicine, Biochemistry, QD415-436
الوصف: Abstract Apocrine carcinoma is a rare breast cancer subtype. As such, the genomic characteristics of apocrine carcinoma with triple negative immunohistochemical results (TNAC), which has been treated as triple negative breast cancer (TNBC), have not been revealed. In this study, we evaluated the genomic characteristics of TNAC compared to TNBC with low Ki-67 (LK-TNBC). In the genetic analysis of 73 TNACs and 32 LK-TNBCs, the most frequently mutated driver gene in TNAC was TP53 (16/56, 28.6%), followed by PIK3CA (9/56, 16.1%), ZNF717 (8/56, 14.3%), and PIK3R1 (6/56, 10.71%). Mutational signature analysis showed enrichment of defective DNA mismatch repair (MMR)-related signatures (SBS6 and SBS21) and the SBS5 signature in TNAC, whereas an APOBEC activity-associated mutational signature (SBS13) was more prominent in LK-TNBC (Student’s t test, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2092-6413
Relation: https://doaj.org/toc/2092-6413
DOI: 10.1038/s12276-023-01030-z
URL الوصول: https://doaj.org/article/d8897389d2f94b6bbb0403cf5292d380
رقم الأكسشن: edsdoj.8897389d2f94b6bbb0403cf5292d380
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20926413
DOI:10.1038/s12276-023-01030-z