دورية أكاديمية
Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers
| العنوان: | Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers |
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| المؤلفون: | Martina Amato, Renato Franco, Gaetano Facchini, Raffaele Addeo, Fortunato Ciardiello, Massimiliano Berretta, Giulia Vita, Alessandro Sgambato, Sandro Pignata, Michele Caraglia, Marina Accardo, Federica Zito Marino |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 15, p 8726 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | microsatellite instability, mismatch repair, immunotherapy, immunohistochemistry, PCR, NGS, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Microsatellite instability (MSI) has been identified in several tumors arising from either germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to immune checkpoint inhibitors (ICIs), particularly PD1/PD-L1 inhibitors. To date, the predictive role of MSI is currently used in the selection of colorectal cancer patients for immunotherapy; moreover, the expansion of clinical trials into other cancer types may elucidate the predictive value of MSI for non-colorectal tumors. In clinical practice, several assays are used for MSI testing, including immunohistochemistry (IHC), polymerase chain reaction (PCR) and next-generation sequencing (NGS). In this review, we provide an overview of MSI in various cancer types, highlighting its potential predictive/prognostic role and the clinical trials performed. Finally, we focus on the comparison data between the different assays used to detect MSI in clinical practice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/15/8726; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23158726 |
| URL الوصول: | https://doaj.org/article/d88b17989bab4c60848acdbb619f790f |
| رقم الأكسشن: | edsdoj.88b17989bab4c60848acdbb619f790f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23158726 |