دورية أكاديمية
The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas
| العنوان: | The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas |
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| المؤلفون: | Bac Thanh Nguyen, Duc Anh Tran, Hung Quang Ngo, Trung Hoang Nguyen, Hoa Khanh Ngo |
| المصدر: | Revista Cubana de Medicina Militar, Vol 53, Iss 2, Pp e024035778-e024035778 (2024) |
| بيانات النشر: | ECIMED, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | genes tp53, mutation, gliomas, treatment outcome., Medicine, Medicine (General), R5-920 |
| الوصف: | Introduction: Determining the relationship between TP53 gene mutation and treatment outcome in high-grade gliomas patients has great significance for disease prognosis and treatment outcome monitoring. Ojectives: To determine the relationship between TP53 gene mutation rate and some characteristics of treatment outcome in high-grade gliomas patients. Methods: The study was conducted by descriptive method, on 52 high-grade gliomas patients at Vietnam National Cancer Hospital, from January 2019 to December 2020. Based on statistics of clinical symptoms, paraclinical tests and post-operative monitoring results, it was evaluated the relationship between TP53 gene mutation in study patients with response to treatment and patient's survival time. Results: There was a relationship between TP53 gene mutation and response to treatment according to Response Evaluation Criteria In Solid Tumors (p= 0.004). Progression-free survival was higher in the group with the TP53 mutation than in the group without the TP53 mutation (χ2= 6.7; p= 0.010). The overall survival in the group with the TP53 mutation was higher than the overall survival in the group without the TP53 mutation (χ2= 2.6; p= 0.107). Conclusion: There is a relationship between the occurrence of TP53 gene mutations with treatment response criteria and progression-free survival in patients with high-grade gliomas. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Spanish; Castilian |
| تدمد: | 1561-3046 |
| Relation: | https://revmedmilitar.sld.cu/index.php/mil/article/view/35778; https://doaj.org/toc/1561-3046 |
| URL الوصول: | https://doaj.org/article/88c00962b9714388aea9c62418189ced |
| رقم الأكسشن: | edsdoj.88c00962b9714388aea9c62418189ced |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15613046 |
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