دورية أكاديمية
DTaP-IPV-HB-Hib vaccine (Hexaxim): an update 10 years after first licensure
| العنوان: | DTaP-IPV-HB-Hib vaccine (Hexaxim): an update 10 years after first licensure |
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| المؤلفون: | Florence Boisnard, Christine Manson, Laurence Serradell, Denis Macina |
| المصدر: | Expert Review of Vaccines, Vol 22, Iss 1, Pp 1196-1213 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | Clinical trial, effectiveness, fully liquid, hexavalent, immunogenicity, pertussis, Internal medicine, RC31-1245 |
| الوصف: | ABSTRACTIntroduction Hexaxim® is fully liquid, hexavalent, combination vaccine that provides immunization against diphtheria, tetanus, pertussis (whooping cough), polio, hepatitis B, and invasive diseases caused by Haemophilus influenzae type b. Combination vaccines such as Hexaxim reduce the number of injections needed, improving both vaccination compliance and operational efficiency.Areas covered Safety and immunogenicity data were reviewed from >25 clinical trials involving approximately 7200 infants/toddlers, identified using PubMed searches to April 2023. These trials have evaluated a diverse range of primary series and booster schedules, including antibody persistence, co-administration of Hexaxim with other routine pediatric vaccines, and specific populations (born to Tdap-vaccinated women, preterm, and immunocompromised infants). Lastly, post-marketing surveillance and real-world effectiveness data were assessed.Expert opinion An extensive program of clinical development prior to licensure demonstrated favorable vaccine safety and good immunogenicity of each antigen, and Hexaxim was first approved for use in 2012. In the 10 years since licensure, Hexaxim has been adopted widely, with more than 180 million doses distributed worldwide. The widespread use of this hexavalent vaccine is a crucial tool in the ongoing and future control of six pediatric infectious diseases globally. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14760584 1744-8395 1476-0584 |
| Relation: | https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395 |
| DOI: | 10.1080/14760584.2023.2280236 |
| URL الوصول: | https://doaj.org/article/88c5e3c0b8e84d7e91627b867cf97313 |
| رقم الأكسشن: | edsdoj.88c5e3c0b8e84d7e91627b867cf97313 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 14760584 17448395 |
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| DOI: | 10.1080/14760584.2023.2280236 |