دورية أكاديمية
أعرض في EDS

Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease

التفاصيل البيبلوغرافية
العنوان: Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
المؤلفون: Shengnan Tang, Aiping Wang, Xiuju Yan, Liuxiang Chu, Xiucheng Yang, Yina Song, Kaoxiang Sun, Xin Yu, Rongxia Liu, Zimei Wu, Peng Xue
المصدر: Drug Delivery, Vol 26, Iss 1, Pp 700-707 (2019)
بيانات النشر: Taylor & Francis Group, 2019.
سنة النشر: 2019
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: dopamine, lactoferrin, borneol, nose-to-brain targeted nanoparticles, parkinson’s disease, Therapeutics. Pharmacology, RM1-950
الوصف: Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. In vitro cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. In vivo pharmacokinetic studies indicated that AUC0–12 h in the rat brain for dopamine Lf-BNPs was significantly higher (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1071-7544
1521-0464
10717544
Relation: https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464
DOI: 10.1080/10717544.2019.1636420
URL الوصول: https://doaj.org/article/88fa8751d7d749edafc991324c85bb2a
رقم الأكسشن: edsdoj.88fa8751d7d749edafc991324c85bb2a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10717544
15210464
DOI:10.1080/10717544.2019.1636420