دورية أكاديمية
Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation
| العنوان: | Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation |
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| المؤلفون: | Elena Tassi, Maddalena Noviello, Pantaleo De Simone, Maria T. Lupo-Stanghellini, Matteo Doglio, Francesca Serio, Danilo Abbati, Valeria Beretta, Veronica Valtolina, Giacomo Oliveira, Sara Racca, Edoardo Campodonico, Eliana Ruggiero, Daniela Clerici, Fabio Giglio, Francesca Lorentino, Roee Dvir, Elisabetta Xue, Francesca Farina, Chiara Oltolini, Francesco Manfredi, Luca Vago, Consuelo Corti, Massimo Bernardi, Massimo Clementi, Liselotte Brix, Fabio Ciceri, Jacopo Peccatori, Raffaella Greco, Chiara Bonini |
| المصدر: | Haematologica, Vol 108, Iss 6 (2022) |
| بيانات النشر: | Ferrata Storti Foundation, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | After allogeneic hematopoietic stem cell transplantation (HSCT), the emergence of circulating cytomegalovirus (CMV)- specific T cells correlates with protection from CMV reactivation, an important risk factor for non-relapse mortality. However, functional assays measuring CMV-specific cells are time-consuming and often inaccurate at early time-points. We report the results of a prospective single-center, non-interventional study that identified the enumeration of Dextramerpositive CMV-specific lymphocytes as a reliable and early predictor of viral reactivation. We longitudinally monitored 75 consecutive patients for 1 year after allogeneic HSCT (n=630 samples). The presence of ≥0.5 CMV-specific CD8+ cells/mL at day +45 was an independent protective factor from subsequent clinically relevant reactivation in univariate (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0390-6078 1592-8721 |
| Relation: | https://haematologica.org/article/view/10813; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721 |
| DOI: | 10.3324/haematol.2022.280685 |
| URL الوصول: | https://doaj.org/article/8932074fa8774b37bf1fd0dea977eb01 |
| رقم الأكسشن: | edsdoj.8932074fa8774b37bf1fd0dea977eb01 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03906078 15928721 |
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| DOI: | 10.3324/haematol.2022.280685 |