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Up-regulated 60S ribosomal protein L18 in PEDV N protein-induced S-phase arrested host cells promotes viral replication

التفاصيل البيبلوغرافية
العنوان: Up-regulated 60S ribosomal protein L18 in PEDV N protein-induced S-phase arrested host cells promotes viral replication
المؤلفون: Qinghe Zhu, Mingjun Su, Shan Wei, Da Shi, Lu Li, Jun Wang, Haibo Sun, Meijiao Wang, Chunqiu Li, Donghua Guo, Dongbo Sun
المصدر: Virus Research, Vol 321, Iss , Pp 198916- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Microbiology
LCC:Infectious and parasitic diseases
مصطلحات موضوعية: coronavirus, PEDV, Cell cycle arrest, Ribosomal protein L18, Virus replication, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
الوصف: Coronavirus subverts the host cell cycle to create a favorable cellular environment that enhances viral replication in host cells. Previous studies have revealed that nucleocapsid (N) protein of the coronavirus porcine epidemic diarrhea virus (PEDV) interacts with p53 to induce cell cycle arrest in S-phase and promotes viral replication. However, the mechanism by which viral replication is increased in the PEDV N protein-induced S-phase arrested cells remains unknown. In the current study, the protein expression profiles of PEDV N protein-induced S-phase arrested Vero E6 cells and thymidine-induced S-phase arrested Vero E6 cells were characterized by tandem mass tag-labeled quantitative proteomic technology. The effect of differentially expressed proteins (DEPs) on PEDV replication was investigated. The results indicated that a total of 5709 proteins, including 20,560 peptides, were identified, of which 58 and 26 DEPs were identified in the PEDV N group and thymidine group, respectively (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1872-7492
Relation: http://www.sciencedirect.com/science/article/pii/S0168170222002441; https://doaj.org/toc/1872-7492
DOI: 10.1016/j.virusres.2022.198916
URL الوصول: https://doaj.org/article/8991c5c35d4a4023b4dd2aad6ccd1a0b
رقم الأكسشن: edsdoj.8991c5c35d4a4023b4dd2aad6ccd1a0b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18727492
DOI:10.1016/j.virusres.2022.198916