دورية أكاديمية
Microarray Core Detection by Geometric Restoration
| العنوان: | Microarray Core Detection by Geometric Restoration |
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| المؤلفون: | Jimmy C. Azar, Christer Busch, Ingrid B. Carlbom |
| المصدر: | Analytical Cellular Pathology, Vol 35, Iss 5-6, Pp 381-393 (2012) |
| بيانات النشر: | Wiley, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Whole-slide imaging of tissue microarrays (TMAs) holds the promise of automated image analysis of a large number of histopathological samples from a single slide. This demands high-throughput image processing to enable analysis of these tissue samples for diagnosis of cancer and other conditions. In this paper, we present a completely automated method for the accurate detection and localization of tissue cores that is based on geometric restoration of the core shapes without placing any assumptions on grid geometry. The method relies on hierarchical clustering in conjunction with the Davies-Bouldin index for cluster validation in order to estimate the number of cores in the image wherefrom we estimate the core radius and refine this estimate using morphological granulometry. The final stage of the algorithm reconstructs circular discs from core sections such that these discs cover the entire region of each core regardless of the precise shape of the core. The results show that the proposed method is able to reconstruct core locations without any evidence of localization. Furthermore, the algorithm is more efficient than existing methods based on the Hough transform for circle detection. The algorithm’s simplicity, accuracy, and computational efficiency allow for automated high-throughput analysis of microarray images. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2210-7177 2210-7185 |
| Relation: | https://doaj.org/toc/2210-7177; https://doaj.org/toc/2210-7185 |
| DOI: | 10.3233/ACP-2012-0067 |
| URL الوصول: | https://doaj.org/article/89a4195bbc4a4cee9d56cc7621cb36a1 |
| رقم الأكسشن: | edsdoj.89a4195bbc4a4cee9d56cc7621cb36a1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22107177 22107185 |
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| DOI: | 10.3233/ACP-2012-0067 |