دورية أكاديمية
Large-scale mechanism hypothesis and research prospects of cognitive impairment in schizophrenia based on magnetic resonance imaging
| العنوان: | Large-scale mechanism hypothesis and research prospects of cognitive impairment in schizophrenia based on magnetic resonance imaging |
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| المؤلفون: | Yue-Wen Gu, Jing-Wen Fan, Shu-Wan Zhao, Xiao-Fan Liu, Hong Yin, Long-Biao Cui |
| المصدر: | Heliyon, Vol 10, Iss 4, Pp e25915- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Schizophrenia, Cognitive impairments, Connectome, Magnetic resonance imaging, Treatment, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Cognitive impairments in schizophrenia are pivotal clinical issues that need to be solved urgently. However, the mechanism remains unknown. It has been suggested that cognitive impairments in schizophrenia are associated with connectome damage, and are especially relevant to the disrupted hub nodes in the frontal and parietal lobes. Activating the dorsolateral prefrontal cortex (DLPFC) via repetitive transcranial magnetic stimulation (rTMS) could result in improved cognition. Based on several previous magnetic resonance imaging (MRI) studies on schizophrenia, we found that the first-episode patients showed connectome damage, as well as abnormal activation and connectivity of the DLPFC and inferior parietal lobule (IPL). Accordingly, we proposed that DLPFC-IPL pathway destruction might mediate connectome damage of cognitive impairments in schizophrenia. In the meantime, with the help of multimodal MRI and noninvasive neuromodulation tool, we may not only validate the hypothesis, but also find IPL as the potential intervention target for cognitive impairments in schizophrenia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024019467; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e25915 |
| URL الوصول: | https://doaj.org/article/ed89b7aa6aa04a65b09ea09a66e26e1f |
| رقم الأكسشن: | edsdoj.89b7aa6aa04a65b09ea09a66e26e1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e25915 |