دورية أكاديمية
Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study
| العنوان: | Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study |
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| المؤلفون: | Kwon Hui Seo, Ji Hyung Hong, Mi Hyoung Moon, Wonjung Hwang, Sea-Won Lee, Jin Young Chon, Hyejin Kwon, Sook Hee Hong, Sukil Kim |
| المصدر: | Korean Journal of Anesthesiology, Vol 76, Iss 4, Pp 336-347 (2023) |
| بيانات النشر: | Korean Society of Anesthesiologists, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Anesthesiology |
| مصطلحات موضوعية: | anesthetics, inhalation, lung neoplasms, non-small cell lung carcinoma, propofol, survival, Anesthesiology, RD78.3-87.3 |
| الوصف: | Background Propofol-based total intravenous anesthesia (TIVA) improves long-term outcomes after cancer surgery compared with inhalation anesthesia. However, its effect on patients undergoing non-small cell lung cancer (NSCLC) surgery remains unclear. We aimed to compare the oncological outcomes of TIVA and inhalation anesthesia after curative resection of early-stage NSCLC. Methods We analyzed the medical records of patients diagnosed with stage I or II NSCLC who underwent curative resection at a tertiary university hospital between January 2010 and December 2017. The primary outcomes were recurrence-free survival (RFS) and overall survival (OS) according to anesthesia type. Results We included 1,508 patients with stage I/II NSCLC. The patients were divided into the TIVA (n = 980) and Inhalation (n = 528) groups. The two groups were well-balanced in terms of baseline clinical characteristics. The TIVA group demonstrated significantly improved RFS (7.7 years, 95% CI [7.37, 8.02]) compared with the Inhalation group (6.8 years, 95% CI [6.30, 7.22], P = 0.003). Similarly, TIVA was superior to inhalation agents with respect to OS (median OS; 8.4 years, 95% CI [8.08, 8.69] vs. 7.3 years, 95% CI [6.81, 7.71]; P < 0.001). Multivariable Cox regression analysis revealed that TIVA was an independent prognostic factor related to recurrence (hazard ratio [HR]: 1.24, 95% CI [1.04, 1.47], P = 0.014) and OS (HR: 1.39, 95% CI [1.12, 1.72], P = 0.002). Conclusions Propofol-based TIVA was associated with better RFS and OS than inhalation anesthesia in patients with stage I/II NSCLC who underwent curative resection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2005-6419 2005-7563 |
| Relation: | http://ekja.org/upload/pdf/kja-22584.pdf; https://doaj.org/toc/2005-6419; https://doaj.org/toc/2005-7563 |
| DOI: | 10.4097/kja.22584 |
| URL الوصول: | https://doaj.org/article/89c2d5b7e3e646848d68114bb96ecca2 |
| رقم الأكسشن: | edsdoj.89c2d5b7e3e646848d68114bb96ecca2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20056419 20057563 |
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| DOI: | 10.4097/kja.22584 |