دورية أكاديمية
Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads
| العنوان: | Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads |
|---|---|
| المؤلفون: | Xiao Lin, Zidi Jin, Shuo Li, Mingde Zheng, Ya Xing, Xikui Liu, Mengqing Lv, Minmeng Zhao, Tuoyu Geng, Daoqing Gong, Debiao Zhao, Long Liu |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 10, p 8891 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | chicken embryo, gonadal development, MIER3, αGSU, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The sex chromosomes of birds are designated Z and W. The male is homogamous (ZZ), and the female is heterogamous (ZW). The chicken W chromosome is a degenerate version of the Z chromosome and harbors only 28 protein-coding genes. We studied the expression pattern of the W chromosome gene MIER3 (showing differential expression during gonadogenesis) in chicken embryonic gonads and its potential role in gonadal development. The W copy of MIER3 (MIER3–W) shows a gonad-biased expression in chicken embryonic tissues which was different from its Z copy. The overall expression of MIER3–W and MIER3–Z mRNA and protein is correlated with the gonadal phenotype being higher in female gonads than in male gonads or female-to-male sex-reversed gonads. Chicken MIER3 protein is highly expressed in the nucleus, with relatively lower expression in the cytoplasm. Overexpression of MIER3–W in male gonad cells suggested its effect on the GnRH signaling pathway, cell proliferation, and cell apoptosis. MIER3 expression is associated with the gonadal phenotype. MIER3 may promote female gonadal development by regulating EGR1 and αGSU genes. These findings enrich our knowledge of chicken W chromosome genes and support a more systematic and in-depth understanding of gonadal development in chickens. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/10/8891; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24108891 |
| URL الوصول: | https://doaj.org/article/c89d35187fbb4589ac775128250706a0 |
| رقم الأكسشن: | edsdoj.89d35187fbb4589ac775128250706a0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms24108891 |