دورية أكاديمية
PO-31 EFFECT OF POOR GLYCEMIC CONTROL ON ARTERIAL STIFFNESS IN PREGNANCY
| العنوان: | PO-31 EFFECT OF POOR GLYCEMIC CONTROL ON ARTERIAL STIFFNESS IN PREGNANCY |
|---|---|
| المؤلفون: | Kim Phan, Yessica-Haydee Gomez, Mohamed Salah Al-azzawi, Amira El-Messidi, Stella S. Daskalopoulou |
| المصدر: | Artery Research, Vol 16 (2016) |
| بيانات النشر: | BMC, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Specialties of internal medicine LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Objectives: Poor glycemic control during pregnancy is associated with increased adverse perinatal outcomes. Our objective was to characterize the association between glycemic control and arterial stiffness in pregnancy. Methods: In this prospective longitudinal study, women with high-risk singleton pregnancies were recruited from obstetrical clinics in Montreal, Canada. Arterial stiffness was measured in women with gestational diabetes (GDM) or pre-existing diabetes mellitus (DM) using applanation tonometry (SphygmoCor; AtCor) starting at 24 weeks’ gestation (the period at which GDM screening is performed for all women according to standard clinical practice) and every 4 weeks thereafter until delivery. Arterial stiffness indices were compared between women with poor glycemic control and women with adequate glycemic control. Poor glycemic control was defined as average HbA1C > 7%, average fasting glucose > 5.3 mmol/L, average 1h post-prandial glucose > 7.8 mmol/L, insulin dosage > 30 units, large for gestational age fetus, or maximal vertical pocket > 8 cm. Results: Of the 35 women who delivered in this ongoing study and had GDM (n=18) or DM (n=17), 12 had poor glycemic control throughout their pregnancy. Longitudinal analyses adjusted for maternal age, body mass index, and medical history, showed women with poor glycemic control had significantly increased carotid-radial pulse wave velocity (PWV) at each timepoint: 26–30 weeks: 8.4 vs. 8.0 m/s, p = 0.04; 30–34 weeks: 8.4 vs. 8.1 m/s, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12593052 1876-4401 |
| Relation: | https://www.atlantis-press.com/article/125930520/view; https://doaj.org/toc/1876-4401 |
| DOI: | 10.1016/j.artres.2016.08.034 |
| URL الوصول: | https://doaj.org/article/c89f73aed62a408ea7291f5d7744faf8 |
| رقم الأكسشن: | edsdoj.89f73aed62a408ea7291f5d7744faf8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 12593052 18764401 |
|---|---|
| DOI: | 10.1016/j.artres.2016.08.034 |