دورية أكاديمية
Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
| العنوان: | Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
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| المؤلفون: | Grace Y. Lam, Jodi Goodwin, Pearce G. Wilcox, Bradley S. Quon |
| المصدر: | ERJ Open Research, Vol 7, Iss 1 (2021) |
| بيانات النشر: | European Respiratory Society, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2312-0541 23120541 |
| Relation: | http://openres.ersjournals.com/content/7/1/00475-2020.full; https://doaj.org/toc/2312-0541 |
| DOI: | 10.1183/23120541.00475-2020 |
| URL الوصول: | https://doaj.org/article/8a1f0a3eb8f84247aec28a87fe8364d1 |
| رقم الأكسشن: | edsdoj.8a1f0a3eb8f84247aec28a87fe8364d1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23120541 |
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| DOI: | 10.1183/23120541.00475-2020 |