دورية أكاديمية
Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis
| العنوان: | Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis |
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| المؤلفون: | Letycia Silvano da Silva, Carlos Henrique Rocha Catalão, Tatiana Tocchini Felippotti, Gabriela Ravanelli de Oliveira- Pelegrin, Sérgio Petenusci, Luis Alexandre Pedro de Freitas, Maria José Alves Rocha |
| المصدر: | Pharmaceutical Biology, Vol 55, Iss 1, Pp 269-276 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | clp, hsp70, nitric oxide, glycaemia, volemia, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Context: Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis. Objective: This study evaluates the biological activities of a curcumin dispersion formulated by spray-drying in experimental sepsis. Materials and methods: Male Wistar rats were subjected to sepsis by caecal ligation and puncture (CLP), controls were sham operated. The animals were treated with curcumin dispersion (100 mg/kg, p.o.) or water for 7 days prior to CLP and at 2 h after surgery. One group was used to analyze curcumin absorption through HPLC; another had the survival rate assessed during 48 h; and from a third group, blood was collected by decapitation to analyze metabolic and inflammatory parameters. Results: The plasma curcumin levels reached 2.5 ng/mL at 4 h, dropped significantly (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1388-0209 1744-5116 13880209 |
| Relation: | https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116 |
| DOI: | 10.1080/13880209.2016.1260598 |
| URL الوصول: | https://doaj.org/article/8a3a87e0b027424f956b92934492d66a |
| رقم الأكسشن: | edsdoj.8a3a87e0b027424f956b92934492d66a |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 13880209 17445116 |
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| DOI: | 10.1080/13880209.2016.1260598 |