دورية أكاديمية
أعرض في EDS

The Mechanism of (R,R) ZX-5 on Increasing NO Release

التفاصيل البيبلوغرافية
العنوان: The Mechanism of (R,R) ZX-5 on Increasing NO Release
المؤلفون: Zilong Shen, Yihua Zhang, Hongying Lin, Weiqiang Wang, Jin Wei, Li Pan, Han-Mei Xu
المصدر: International Journal of Molecular Sciences, Vol 11, Iss 9, Pp 3323-3333 (2010)
بيانات النشر: MDPI AG, 2010.
سنة النشر: 2010
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: (R,R) ZX-5, iNOS, eNOS, ERK, Akt, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: (R,R) ZX-5 has been proven to have positive effects on choroidal blood flow without affecting the sclera and ciliary bodies in New Zealand white rabbits. This study was designed to investigate the mechanisms of (R,R) ZX-5 on improving the choroidal blood flow and promoting NO production. HUVECs (human umbilical vein endothelial cells) were used to determine the production of eNOS, p-eNOS, AKT and Erk1/2 by Western blot analysis. iNOS and eNOS mRNA levels were investigated by RT-PCR and the effect of (R,R) ZX-5 on NO production were determined by eNOS activity assay. We found (R,R) ZX-5 upregulated protein expression of eNOS and iNOS, increased NO production, and reduced ERK and Akt protein level. Therefore, (R,R) ZX-5 may promote the choroidal blood flow in New Zealand white rabbits without affecting the blood flow in the iris or ciliary bodies via increasing NO production. These results suggest that (R,R) ZX-5 may function to cure and prevent Age-related macular degeneration (AMD).
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 11093323
1422-0067
Relation: http://www.mdpi.com/1422-0067/11/9/3323/; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms11093323
URL الوصول: https://doaj.org/article/8a3dfe7bf96c4145877cbebe001085a7
رقم الأكسشن: edsdoj.8a3dfe7bf96c4145877cbebe001085a7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11093323
14220067
DOI:10.3390/ijms11093323