دورية أكاديمية
PCV15, a pneumococcal conjugate vaccine, for the prevention of invasive pneumococcal disease in infants and children
| العنوان: | PCV15, a pneumococcal conjugate vaccine, for the prevention of invasive pneumococcal disease in infants and children |
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| المؤلفون: | Timothy J Chapman, Liset Olarte, Ghassan Dbaibo, Avril Melissa Houston, Gretchen Tamms, Robert Lupinacci, Kristen Feemster, Ulrike K Buchwald, Natalie Banniettis |
| المصدر: | Expert Review of Vaccines, Vol 23, Iss 1, Pp 137-147 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | Immunogenicity, PCV15, pediatric, phase 3, pneumococcal conjugate vaccine, pneumonia, Internal medicine, RC31-1245 |
| الوصف: | ABSTRACTIntroduction Streptococcus pneumoniae is a causative agent of pneumonia and acute otitis media (AOM), as well as invasive diseases such as meningitis and bacteremia. PCV15 (V114) is a new 15-valent pneumococcal conjugate vaccine (PCV) approved for use in individuals ≥6 weeks of age for the prevention of pneumonia, AOM, and invasive pneumococcal disease.Areas Covered This review summarizes the V114 Phase 3 development program leading to approval in infants and children, including pivotal studies, interchangeability and catch-up vaccination studies, and studies in at-risk populations. An integrated safety summary is presented in addition to immunogenicity and concomitant use of V114 with other routine pediatric vaccines.Expert Opinion Across the development program, V114 demonstrated a safety profile that is comparable to PCV13 in infants and children. Immunogenicity of V114 is comparable to PCV13 for all shared serotypes except serotype 3, where V114 demonstrated superior immunogenicity. Higher immune responses were demonstrated for V114 serotypes 22F and 33F. Results of the ongoing study to evaluate V114 efficacy against vaccine-type pneumococcal AOM and anticipated real-world evidence studies will support assessment of vaccine effectiveness and impact, with an additional question of whether higher serotype 3 immunogenicity translates to better protection against serotype 3 pneumococcal disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14760584 1744-8395 1476-0584 |
| Relation: | https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395 |
| DOI: | 10.1080/14760584.2023.2294153 |
| URL الوصول: | https://doaj.org/article/8a4c9057ccf6425a95168278db4e417f |
| رقم الأكسشن: | edsdoj.8a4c9057ccf6425a95168278db4e417f |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 14760584 17448395 |
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| DOI: | 10.1080/14760584.2023.2294153 |