دورية أكاديمية
أعرض في EDS

Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer

التفاصيل البيبلوغرافية
العنوان: Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer
المؤلفون: Hengfei Gao, Kangkang Ji, Linsen Bao, Hao Chen, Chen Lin, Min Feng, Liang Tao, Meng Wang
المصدر: World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-12 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Surgery
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Gastric cancer, Claudin18.2, CA125, Occult peritoneal metastasis, Nomogram, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Background To investigate the risk factors associated with the development of occult peritoneal metastasis in advanced gastric cancer, and establish and externally validate a nomogram for predicting the occurrence of occult peritoneal metastasis in patients with advanced gastric cancer. Methods A total of 111 patients with advanced gastric cancer who underwent laparoscopic exploration or peritoneal lavage cytology examination at the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 2014 to December 2021 were retrospectively analyzed. The patients diagnosed between 2019 and 2021 were assigned to the training set (n = 64), while those diagnosed between 2014 and 2016 constituted the external validation set (n = 47). In the training set, patients were classified into two groups based on preoperative imaging and postoperative pathological data: the occult peritoneal metastasis group (OPMG) and the peritoneal metastasis negative group (PMNG). In the validation set, patients were classified into the occult peritoneal metastasis group (CY1P0, OPMG) and the peritoneal metastasis negative group (CY0P0, PMNG) based on peritoneal lavage cytology results. A nomogram was constructed using univariate and multivariate analyses. The performance of the nomogram was evaluated using Harrell’s C-index, the area under the receiver operating characteristic curve (AUC), decision curve analysis (DCA), and calibration plots. Results This study analyzed 22 potential variables of OPM in 111 gastric cancer patients who underwent laparoscopic exploration or peritoneal lavage cytology examination. Logistic regression analysis results showed that Lauren classification, CLDN18.2 score and CA125 were independent risk factors for OPM in patients with gastric cancer. We developed a simple and easy-to-use prediction nomogram of occult peritoneal metastasis in advanced gastric cancer. This nomogram had an excellent diagnostic performance. The AUC of the bootstrap model in the training set was 0.771 and in the validation set was 0.711. This model showed a good fitting and calibration and positive net benefits in decision curve analysis. Conclusion We have developed a prediction nomogram of OPM for gastric cancer. This novel nomogram has the potential to enhance diagnostic accuracy for occult peritoneal metastasis in gastric cancer patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1477-7819
Relation: https://doaj.org/toc/1477-7819
DOI: 10.1186/s12957-023-03188-2
URL الوصول: https://doaj.org/article/8a5af29591ea4e08a58aa96bcf97b4a7
رقم الأكسشن: edsdoj.8a5af29591ea4e08a58aa96bcf97b4a7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14777819
DOI:10.1186/s12957-023-03188-2