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Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics

التفاصيل البيبلوغرافية
العنوان: Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics
المؤلفون: Yajun Wu, Hua Fan, Yuliang Feng, Jiasong Yang, Xiaobo Cen, Wensheng Li
المصدر: Heliyon, Vol 10, Iss 9, Pp e30491- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: Form deprivation myopia, 16S ribosomal RNA gene sequencing, Untargeted metabolomics, Gut microbiota, Metabolite, Vasoactive intestinal peptide, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Aim: The aim of this study was to confirm the presence of the form deprivation myopia (FDM) guinea pig eye-gut axis and investigate the relationship between serum vasoactive intestinal peptide (VIP), lipopolysaccharides (LPS), specific gut microbiota and their metabolites. Method: 20 specific-pathogen-free (SPF) guinea pigs were divided into the FDM and the control(Con) group. Following model induction, serum levels of VIP and LPS were quantified. A combination of 16S ribosomal ribosomal Ribonucleic Acid (rRNA) gene sequencing, non-targeted metabolomics and bioinformatics analysis were employed to identify disparities in gut microbiota and metabolites between the two groups of guinea pigs. Result: Compared to the control group, FDM guinea pigs exhibited a significant trend towards myopia, along with significantly elevated concentrations of LPS and VIP (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844024065228; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2024.e30491
URL الوصول: https://doaj.org/article/8a6315b4e57f4689a54cce4f10686ddc
رقم الأكسشن: edsdoj.8a6315b4e57f4689a54cce4f10686ddc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2024.e30491