دورية أكاديمية
Research Progress of Warburg Effect in Hepatocellular Carcinoma
| العنوان: | Research Progress of Warburg Effect in Hepatocellular Carcinoma |
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| المؤلفون: | Yanguang Yang, Yuting Gao, Yajun Xiong, Yi Gong, Junlan Lu, Yuman Zhang, Dan Wang, Zhihan Liu, Xinli Shi |
| المصدر: | Frontiers in Bioscience-Landmark, Vol 29, Iss 5, p 178 (2024) |
| بيانات النشر: | IMR Press, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biochemistry LCC:Biology (General) |
| مصطلحات موضوعية: | warburg effect, hepatocellular carcinoma, tumor microenvironment, Biochemistry, QD415-436, Biology (General), QH301-705.5 |
| الوصف: | The Warburg effect, also called aerobic glycolysis, refers to tumor cells that metabolize glucose through glycolysis even in the presence of oxygen. This rapid breakdown of glucose fuels the fast development, growth, and migration of tumor cells. Lactate, the final product of aerobic glycolysis, contributes to an acidic environment within the tumor, promoting the formation of an immunosuppressive microenvironment and accelerating tumor progression by impeding anti-tumor immunity. Numerous studies have confirmed the critical role of aerobic glycolysis in the occurrence and development of hepatocellular carcinoma by influencing tumor cells proliferation, invasion, metastasis, apoptosis, immune escape, angiogenesis, and more. Clinical trials have shown that inhibitors of rate-limiting enzymes in the glycolysis pathway can enhance the effectiveness of sorafenib, a targeted drug for hepatocellular carcinoma, by reducing drug resistance. Additionally, active components of traditional Chinese medicine and specific compound prescriptions are gaining attention for their potential to target and regulate aerobic glycolysis in hepatocellular carcinoma. Therefore, inhibiting the aerobic glycolysis pathway holds promise as a therapeutic strategy for treating liver tumors. This manuscript aims to review the role, research directions, and clinical studies of aerobic glycolysis in hepatocellular carcinoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2768-6701 |
| Relation: | https://www.imrpress.com/journal/FBL/29/5/10.31083/j.fbl2905178; https://doaj.org/toc/2768-6701 |
| DOI: | 10.31083/j.fbl2905178 |
| URL الوصول: | https://doaj.org/article/8aca060486f249ca82abc774511c3474 |
| رقم الأكسشن: | edsdoj.8aca060486f249ca82abc774511c3474 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27686701 |
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| DOI: | 10.31083/j.fbl2905178 |