دورية أكاديمية
Sensitive and prolonged intracellular electrophysiological recording by three‐dimensional nanodensity regulation
| العنوان: | Sensitive and prolonged intracellular electrophysiological recording by three‐dimensional nanodensity regulation |
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| المؤلفون: | Xingxing Liu, Dongxin Xu, Jiaru Fang, Yuheng Liao, Mingyue Zhang, Hongbo Li, Wenjian Yang, Yue Wu, Zhongyuan Xu, Ning Hu, Diming Zhang |
| المصدر: | View, Vol 4, Iss 6, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | cardiomyocytes, intracellular recording, nanodensity regulation, tunable nanodensity electrode arrays, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract With the advancement of micro/nanotechnologies, multielectrodes arrays (MEAs) with different three‐dimensional (3D) micro/nanostructures have been developed to achieve intracellular action potential recording of cardiomyocytes. However, the effect of the 3D micro/nanostructures density on the intracellular recording has not been fully investigated. In this work, 3D tunable nanodensity electrode arrays (TNDEA) are fabricated by hydrothermal synthesis and standard microfabrication to explore the effect of nanodensity regulation on intracellular biosensing. By low‐voltage electroporation, the signal quality of intracellular potentials recorded by the low‐nanodensity TNDEA showed was significantly improved compared to those recorded by the high‐nanodensity TNDEA. The low‐nanodensity TNDEA improved the amplitude (up to 7.7 mV), signal‐to‐noise ratio (SNR) (up to 69.46 dB), recording duration (up to 83 min), and recording yield (∼100%). The 3D nanodensity regulating strategy has achieved sensitive and prolonged intracellular biosensing of action potentials and is expected to be a powerful electrophysiological research tool in the biomedical field. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2688-268X 2688-3988 |
| Relation: | https://doaj.org/toc/2688-3988; https://doaj.org/toc/2688-268X |
| DOI: | 10.1002/VIW.20230031 |
| URL الوصول: | https://doaj.org/article/8acfa0dad87740908e2b4c678a358660 |
| رقم الأكسشن: | edsdoj.8acfa0dad87740908e2b4c678a358660 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2688268X 26883988 |
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| DOI: | 10.1002/VIW.20230031 |