دورية أكاديمية
Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles
| العنوان: | Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles |
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| المؤلفون: | Dennis Kaden, Lars Dähne, Fanny Knorr, Heike Richter, Jürgen Lademann, Martina C. Meinke, Alexa Patzelt, Maxim E. Darvin, Sora Jung |
| المصدر: | Sensors, Vol 20, Iss 18, p 5243 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Chemical technology |
| مصطلحات موضوعية: | triggered drug release, follicular penetration, skin barrier, skin acidity, Chemical technology, TP1-1185 |
| الوصف: | Nanoparticles can be applied to the hair follicles, which can serve as reservoirs for triggered drug release. A valid measurement method for the determination of the pH within the hair follicle in vivo has not been shown yet. Here, melamine formaldehyde particles up to 9 µm in size were applied on 40 freshly plucked scalp hairs of eight individuals to determine the pH along the hair shaft down to the root area of the hair. For fluorescent pH indicators, pyranine and Nile blue were incorporated into the particles. Measurements were conducted using confocal laser scanning microscopy. A pH decay gradient could be found from the hair sheath towards the external hair shaft (p = 0.012) with pH values at the hair sheath of 6.63 ± 0.09, at the hair sheath end at 6.33 ± 0.11, and at the external hair shaft at 6.17 ± 0.09 (mean ± SE). The pH difference between the hair sheath end and the external hair shaft was found to be significant (p = 0.036). The results might be comparable with the pH within the hair follicle in vivo indicating a pH increase towards the hair root. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 20185243 1424-8220 |
| Relation: | https://www.mdpi.com/1424-8220/20/18/5243; https://doaj.org/toc/1424-8220 |
| DOI: | 10.3390/s20185243 |
| URL الوصول: | https://doaj.org/article/8b2c667e5f3f4597aa79be9422082e9c |
| رقم الأكسشن: | edsdoj.8b2c667e5f3f4597aa79be9422082e9c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20185243 14248220 |
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| DOI: | 10.3390/s20185243 |