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Chronic restraint stress induces sperm acrosome reaction and changes in testicular tyrosine phosphorylated proteins in rats

التفاصيل البيبلوغرافية
العنوان: Chronic restraint stress induces sperm acrosome reaction and changes in testicular tyrosine phosphorylated proteins in rats
المؤلفون: Supatcharee Arun, Jaturon Burawat, Wannisa Sukhorum, Apichakan Sampannang, Chanwit Maneenin, Sitthichai Iamsaard
المصدر: Iranian Journal of Reproductive Medicine, Vol 14, Iss 7, Pp 443-452 (2016)
بيانات النشر: Shahid Sadoughi University of Medical Science, Yazd, Iran, 2016.
سنة النشر: 2016
المجموعة: LCC:Gynecology and obstetrics
LCC:Reproduction
مصطلحات موضوعية: Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
الوصف: Background: Stress is a cause of male infertility. Although sex hormones and sperm quality have been shown to be low in stress, sperm physiology and testicular functional proteins, such as phosphotyrosine proteins, have not been documented. Objective: To investigate the acrosome status and alterations of testicular proteins involved in spermatogenesis and testosterone synthesis in chronic stress in rats. Materials and Methods: In this experimental study, male rats were divided into 2 groups (control and chronic stress (CS), n=7). CS rats were immobilized (4 hr/day) for 42 consecutive days. The blood glucose level (BGL), corticosterone, testosterone, acrosome status, and histopathology were examined. The expressions of testicular steroidogenic acute regulatory (StAR), cytochrome P450 side chain cleavage (CYP11A1), and phosphorylated proteins were analyzed. Results: Results showed that BGL (71.25±2.22 vs. 95.60±3.36 mg/dl), corticosterone level (24.33±4.23 vs. 36.9±2.01 ng/ml), acrosome reacted sperm (3.25±1.55 vs. 17.71±5.03%), and sperm head abnormality (3.29±0.71 vs. 6.21±1.18%) were significantly higher in CS group in comparison with control. In contrast, seminal vesicle (0.41±0.05 vs. 0.24±0.07 g/100g), testosterone level (3.37±0.79 vs. 0.61±0.29 ng/ml), and sperm concentration (115.33±7.70 vs. 79.13±3.65×106 cells/ml) of CS were significantly lower (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1680-6433
2008-2177
Relation: http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/2013/1000; https://doaj.org/toc/1680-6433; https://doaj.org/toc/2008-2177
URL الوصول: https://doaj.org/article/8b4d668756c84d7fbfa9952dff5a2ad6
رقم الأكسشن: edsdoj.8b4d668756c84d7fbfa9952dff5a2ad6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16806433
20082177