دورية أكاديمية
Brain tissue oxygenation guided therapy and outcome in non-traumatic subarachnoid hemorrhage
| العنوان: | Brain tissue oxygenation guided therapy and outcome in non-traumatic subarachnoid hemorrhage |
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| المؤلفون: | Elisa Gouvea Bogossian, Daniela Diaferia, Narcisse Ndieugnou Djangang, Marco Menozzi, Jean-Louis Vincent, Marta Talamonti, Olivier Dewitte, Lorenzo Peluso, Sami Barrit, Mejdeddine Al Barajraji, Joachim Andre, Sophie Schuind, Jacques Creteur, Fabio Silvio Taccone |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Brain hypoxia can occur after non-traumatic subarachnoid hemorrhage (SAH), even when levels of intracranial pressure (ICP) remain normal. Brain tissue oxygenation (PbtO2) can be measured as a part of a neurological multimodal neuromonitoring. Low PbtO2 has been associated with poor neurologic recovery. There is scarce data on the impact of PbtO2 guided-therapy on patients’ outcome. This single-center cohort study (June 2014–March 2020) included all patients admitted to the ICU after SAH who required multimodal monitoring. Patients with imminent brain death were excluded. Our primary goal was to assess the impact of PbtO2-guided therapy on neurological outcome. Secondary outcome included the association of brain hypoxia with outcome. Of the 163 patients that underwent ICP monitoring, 62 were monitored with PbtO2 and 54 (87%) had at least one episode of brain hypoxia. In patients that required treatment based on neuromonitoring strategies, PbtO2-guided therapy (OR 0.33 [CI 95% 0.12–0.89]) compared to ICP-guided therapy had a protective effect on neurological outcome at 6 months. In this cohort of SAH patients, PbtO2-guided therapy might be associated with improved long-term neurological outcome, only when compared to ICP-guided therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-95602-6 |
| URL الوصول: | https://doaj.org/article/e8b73e38d26048f78b890397879104fb |
| رقم الأكسشن: | edsdoj.8b73e38d26048f78b890397879104fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-95602-6 |