دورية أكاديمية
Spermatozoan Metabolism as a Non-Traditional Model for the Study of Huntington’s Disease
| العنوان: | Spermatozoan Metabolism as a Non-Traditional Model for the Study of Huntington’s Disease |
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| المؤلفون: | Meghan Lawlor, Michal Zigo, Karl Kerns, In Ki Cho, Charles A. Easley IV, Peter Sutovsky |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 13, p 7163 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Huntington’s disease pathway, male infertility, spermatozoa, zinc-containing/interacting proteins, Huntington’s disease model, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Huntington’s Disease (HD) is a fatal autosomal dominant neurodegenerative disease manifested through motor dysfunction and cognitive deficits. Decreased fertility is also observed in HD animal models and HD male patients, due to altered spermatogenesis and sperm function, thus resulting in reduced fertilization potential. Although some pharmaceuticals are currently utilized to mitigate HD symptoms, an effective treatment that remedies the pathogenesis of the disease is yet to be approved by the FDA. Identification of genes and relevant diagnostic biomarkers and therapeutic target pathways including glycolysis and mitochondrial complex-I-dependent respiration may be advantageous for early diagnosis, management, and treatment of the disease. This review addresses the HD pathway in neuronal and sperm metabolism, including relevant gene and protein expression in both neurons and spermatozoa, indicated in the pathogenesis of HD. Furthermore, zinc-containing and zinc-interacting proteins regulate and/or are regulated by zinc ion homeostasis in both neurons and spermatozoa. Therefore, this review also aims to explore the comparative role of zinc in both neuronal and sperm function. Ongoing studies aim to characterize the products of genes implicated in HD pathogenesis that are expressed in both neurons and spermatozoa to facilitate studies of future treatment avenues in HD and HD-related male infertility. The emerging link between zinc homeostasis and the HD pathway could lead to new treatments and diagnostic methods linking genetic sperm defects with somatic comorbidities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/13/7163; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23137163 |
| URL الوصول: | https://doaj.org/article/8b813876f4c34624b92d643dc072285e |
| رقم الأكسشن: | edsdoj.8b813876f4c34624b92d643dc072285e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23137163 |