دورية أكاديمية
أعرض في EDS

Assessment of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) before and after allogeneic hematopoietic stem cell transplantation in acute leukemia patients

التفاصيل البيبلوغرافية
العنوان: Assessment of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) before and after allogeneic hematopoietic stem cell transplantation in acute leukemia patients
المؤلفون: Pierre Peterlin, Marie C. Béné, Maxime Jullien, Thierry Guillaume, Amandine Le Bourgeois, Alice Garnier, Camille Debord, Marion Eveillard, Patrice Chevallier
المصدر: eJHaem, Vol 4, Iss 4, Pp 1089-1095 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: ALL, Allo‐HSCT, AML, diagnosis, MDSC, monocytes, Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: Abstract In this monocentric prospective study, the influence on long‐term outcomes of peripheral blood levels of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) was investigated in 56 patients with acute leukemia (myeloid n = 47; lymphoid n = 9) before and after (Days+60/+90) allogeneic hematopoietic stem cell transplantation (Allo‐HSCT). A risk of relapse was found to be associated with a level of pregraft M‐MDSC above 1.4% by ROC curve analysis. In multivariate analysis, this threshold retained a strong statistical significance (HR: 5.94 [2.09–16.87], p = 0.001). Considering only the group of patients who were in complete remission prior to Allo‐HSCT (n = 44), a significant prediction of relapse was found to be associated, in multivariate analysis, with a level of pregraft M‐MDSC above 1.4% (HR: 55.01 [14.95–202.37], p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2688-6146
Relation: https://doaj.org/toc/2688-6146
DOI: 10.1002/jha2.795
URL الوصول: https://doaj.org/article/8ba3e1e2649e436eb537937b373ae19a
رقم الأكسشن: edsdoj.8ba3e1e2649e436eb537937b373ae19a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26886146
DOI:10.1002/jha2.795