دورية أكاديمية
Assessment of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) before and after allogeneic hematopoietic stem cell transplantation in acute leukemia patients
العنوان: | Assessment of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) before and after allogeneic hematopoietic stem cell transplantation in acute leukemia patients |
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المؤلفون: | Pierre Peterlin, Marie C. Béné, Maxime Jullien, Thierry Guillaume, Amandine Le Bourgeois, Alice Garnier, Camille Debord, Marion Eveillard, Patrice Chevallier |
المصدر: | eJHaem, Vol 4, Iss 4, Pp 1089-1095 (2023) |
بيانات النشر: | Wiley, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Diseases of the blood and blood-forming organs |
مصطلحات موضوعية: | ALL, Allo‐HSCT, AML, diagnosis, MDSC, monocytes, Diseases of the blood and blood-forming organs, RC633-647.5 |
الوصف: | Abstract In this monocentric prospective study, the influence on long‐term outcomes of peripheral blood levels of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) was investigated in 56 patients with acute leukemia (myeloid n = 47; lymphoid n = 9) before and after (Days+60/+90) allogeneic hematopoietic stem cell transplantation (Allo‐HSCT). A risk of relapse was found to be associated with a level of pregraft M‐MDSC above 1.4% by ROC curve analysis. In multivariate analysis, this threshold retained a strong statistical significance (HR: 5.94 [2.09–16.87], p = 0.001). Considering only the group of patients who were in complete remission prior to Allo‐HSCT (n = 44), a significant prediction of relapse was found to be associated, in multivariate analysis, with a level of pregraft M‐MDSC above 1.4% (HR: 55.01 [14.95–202.37], p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2688-6146 |
Relation: | https://doaj.org/toc/2688-6146 |
DOI: | 10.1002/jha2.795 |
URL الوصول: | https://doaj.org/article/8ba3e1e2649e436eb537937b373ae19a |
رقم الأكسشن: | edsdoj.8ba3e1e2649e436eb537937b373ae19a |
قاعدة البيانات: | Directory of Open Access Journals |
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