دورية أكاديمية
C-peptide levels and the prevalence of islets autoantibodies in children with type 1 diabetes mellitus with different duration of the disease
| العنوان: | C-peptide levels and the prevalence of islets autoantibodies in children with type 1 diabetes mellitus with different duration of the disease |
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| المؤلفون: | E. M. Romanenkova, I. A. Eremina, E. V. Titovich, E. A. Sechko, L. V. Nikankina, V. A. Peterkova, O. B. Bezlepkina, D. N. Laptev |
| المصدر: | Сахарный диабет, Vol 25, Iss 2, Pp 155-165 (2022) |
| بيانات النشر: | Endocrinology Research Centre, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | type 1 diabetes, c-peptide, autoantibodies, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | BACKGROUND: Type 1 diabetes mellitus (T1DM) is characterized by the development of absolute insulin deficiency. In some patients residual insulin secretion may persist for a long time. C-peptide is a widely used to measure the pancreatic beta cells function, in clinical practice and in research studies.AIM: To assess C-peptide levels and presence of islets autoantibodies (Ab) in children with different duration of T1DM and to identify factors associated with the preserved secretion.MATERIALS AND METHODS: Single-center cross-sectional study including data from 703 cases of children with T1DM, examined in the Endocrinology Research Center in 2016-2020, who was underwent a study of C-peptide levels and was positive for one or more islets antibodies (ZnT8, IA-2, GAD, ICA, IAA). There were 3 groups of patients: 1st — T1DM duration 5 years.RESULTS: The median of the fasting C-peptide level in the 1st group was 0.6 ng/ml [0.27; 1.09]; in the 2nd group — 0.2 ng/ml [0.01; 0.8]; in the 3rd group — 0.01 ng/ml [0.01; 0.037]. The preserved secretion of C-peptide (> 0.6 ng/ml) was determined in 51.4% in the 1st group, in 31.4% — in the 2nd group and in 11.4% in the 3rd group. In patients with obesity during the first year from the T1DM diagnosis C-peptide levels above 1.1 ng/ml was determined significantly more often (65.2%), as well as at the period of 1 to 5 years of the disease (35.7%), compared with children with normal BMI (18.5% and 14.5%, respectively) or overweight (15.7% and 19%, respectively), p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2072-0351 2072-0378 |
| Relation: | https://www.dia-endojournals.ru/jour/article/view/12843; https://doaj.org/toc/2072-0351; https://doaj.org/toc/2072-0378 |
| DOI: | 10.14341/DM12843 |
| URL الوصول: | https://doaj.org/article/8bac16334d734164ba83b7c610883fb8 |
| رقم الأكسشن: | edsdoj.8bac16334d734164ba83b7c610883fb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20720351 20720378 |
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| DOI: | 10.14341/DM12843 |