دورية أكاديمية
An asymmetric catalytic multi-component reaction enabled the green synthesis of isoserine derivatives and semi-synthesis of paclitaxel
| العنوان: | An asymmetric catalytic multi-component reaction enabled the green synthesis of isoserine derivatives and semi-synthesis of paclitaxel |
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| المؤلفون: | Taoda Shi, Xinglin Li, Yukai Li, Xiang Fu, Linna Wu, Dengqing Wu, Wenhao Hu |
| المصدر: | Green Synthesis and Catalysis, Vol 4, Iss 1, Pp 58-63 (2023) |
| بيانات النشر: | KeAi Communications Co. Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Chemical technology LCC:Biochemistry |
| مصطلحات موضوعية: | Asymmetric catalysis, Multi-component reaction, Green semi-synthesis, Paclitaxel, Chemical technology, TP1-1185, Biochemistry, QD415-436 |
| الوصف: | Paclitaxel (Taxol@) as a cornerstone of chemotherapy remains in high demand. The semi-synthesis of paclitaxel via coupling of Taxus leaf-produced baccatin III and manually synthesized isoserine (C-13 side chain) is one of the solutions to avoid environmental damage caused by the sacrifice of the whole Taxus brevifolia. A green synthesis of the C-13 side chain is pivotal to the green production of paclitaxel. We herein report a green synthesis of isoserine derivatives and the semi-synthesis of paclitaxel via a straightforward assembly of isoserines based on an Rh2(TPA)3(OAc)/CPA1 co-catalyzed asymmetric multi-component reaction of ethyl diazoacetate, triethyl silanol and N-(anthrancen-9-ylmethyl)benzaldimine. The method is featured by improved atom economy, effective mass yield, and environmental factors compared to our previous racemic method and BMS company's semi-synthesis method. And the method allows for rapid access to paclitaxel derivatives with varied C-13 side chains. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2666-5549 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666554922000473; https://doaj.org/toc/2666-5549 |
| DOI: | 10.1016/j.gresc.2022.05.008 |
| URL الوصول: | https://doaj.org/article/d8bcdb2686584ed3b44ff928039070e5 |
| رقم الأكسشن: | edsdoj.8bcdb2686584ed3b44ff928039070e5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26665549 |
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| DOI: | 10.1016/j.gresc.2022.05.008 |