دورية أكاديمية
Synthesis of 4-Hydroxy-2-Methylchalcone from meta-Cresol Formilation Product and Its Activities as an Antibacteria
| العنوان: | Synthesis of 4-Hydroxy-2-Methylchalcone from meta-Cresol Formilation Product and Its Activities as an Antibacteria |
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| المؤلفون: | Ismiyarto Ismiyarto, Suyanti Suyanti, Ngadiwiyana Ngadiwiyana, Purbowatiningrum Ria Sarjono, Nor Basid Adiwibawa Prasetya |
| المصدر: | Jurnal Kimia Sains dan Aplikasi, Vol 21, Iss 4, Pp 193-197 (2018) |
| بيانات النشر: | Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | claisen-schmidt, chalcone, reimer-tiemann, antibacterial, Chemistry, QD1-999 |
| الوصف: | Research on the synthesis of 4-hydroxy-2-methylchalcone from 4-hidroksi-2-metilbenzaldehida as formilated meta-cresol product and its antibacterial activity test has been conducted. As the first step, synthesis of 4-hydroxy-2-methylbenzaldehyde was carried out by treatment meta-cresol with chloroform through the Reimer-Tiemann formylation. Product is a brown solid with 23.94% yields. Furthermore, the 4-hydroxy-2-methylchalcone was synthesized using the 4-hydroxy-2-methylbenzaldehyde and acetophenone through the Claisen-Schmidt reaction. The product is a brownish yellow solid with 29.74% yields. Antibacterial test against Escherichia coli and Staphylococcus aureus bacteria was carried out by comparing the activity of 4-hydroxy-2-methylchalcone with 4-hydroxy-3-methoxychalcone, and chalcone compounds. The antibacterial activity test showed that the 4-hydroxy-2-methylchalcone compound, 4-hydroxy-3-methoxychalcone, and chalcone compounds gave a better antibacterial activity against Escherichia coli than the Staphylococcus aureus. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Indonesian |
| تدمد: | 1410-8917 2597-9914 |
| Relation: | https://ejournal.undip.ac.id/index.php/ksa/article/view/19973; https://doaj.org/toc/1410-8917; https://doaj.org/toc/2597-9914 |
| DOI: | 10.14710/jksa.21.4.193-197 |
| URL الوصول: | https://doaj.org/article/8c0e45677fdc4061bb6e9a72aa61d886 |
| رقم الأكسشن: | edsdoj.8c0e45677fdc4061bb6e9a72aa61d886 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14108917 25979914 |
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| DOI: | 10.14710/jksa.21.4.193-197 |