دورية أكاديمية
Flow chemistry in the multi-step synthesis of natural products
| العنوان: | Flow chemistry in the multi-step synthesis of natural products |
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| المؤلفون: | Li Wan, Gaopan Kong, Minjie Liu, Meifen Jiang, Dang Cheng, Fener Chen |
| المصدر: | Green Synthesis and Catalysis, Vol 3, Iss 3, Pp 243-258 (2022) |
| بيانات النشر: | KeAi Communications Co. Ltd., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemical technology LCC:Biochemistry |
| مصطلحات موضوعية: | Flow chemistry, Multi-step synthesis, Natural products, Microreactor, In-line separation, Chemical technology, TP1-1185, Biochemistry, QD415-436 |
| الوصف: | The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades, performing chemical transformations in continuous flow using various types of microreactors and in-line auxiliary technologies have been demonstrated effectively in respects of enhanced reaction yield and selectivity, excellent reproducibility and easy scale-up, safe proceeding hazardous reaction. And the rapid synthesis of natural products, which has been enabled in continuous flow based upon the significant improvement of overall yield within a short residence time via processing intensification and systematic automation, is essential to furnish sufficient quantity for the bioactivity investigation of structural diversity modification, structure-activity relationship during drug discovery and the increasing consumption of medical treatment. In this review, the multi-step continuous flow synthesis of natural products is highlighted to provide a comprehensive recognization on the intrinsic merits of flow chemistry for organic chemists to purposefully develop the flow synthetic approaches of natural products in the future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2666-5549 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666554922000795; https://doaj.org/toc/2666-5549 |
| DOI: | 10.1016/j.gresc.2022.07.007 |
| URL الوصول: | https://doaj.org/article/8c5dceccaf154f8d8328c8f79016f19e |
| رقم الأكسشن: | edsdoj.8c5dceccaf154f8d8328c8f79016f19e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26665549 |
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| DOI: | 10.1016/j.gresc.2022.07.007 |