دورية أكاديمية
أعرض في EDS

BAFF/APRIL pathway in Sjögren syndrome and systemic lupus erythematosus: relationship with chronic inflammation and disease activity

التفاصيل البيبلوغرافية
العنوان: BAFF/APRIL pathway in Sjögren syndrome and systemic lupus erythematosus: relationship with chronic inflammation and disease activity
المؤلفون: A. Rigon, M. Lo Vullo, F. Buzzulini, D. Sambataro, D. Margiotta, M. Vadacca, A. Afeltra
المصدر: Reumatismo, Vol 62, Iss 4, Pp 259-265 (2011)
بيانات النشر: PAGEPress Publications, 2011.
سنة النشر: 2011
المجموعة: LCC:Medicine
LCC:Internal medicine
مصطلحات موضوعية: Medicine, Internal medicine, RC31-1245
الوصف: Objectives: BAFF and APRIL belong to the tumor necrosis factor (TNF) superfamily and are crucial for the survival, maturation, and differentiation of B cells. Aim of the study is to evaluate BAFF and APRIL in patients affected by Sjögren syndrome (SS) and systemic lupus erythematosus (SLE). Methods: Sixty patients, (40 SLE, 20 SS) and 20 healthy subjects were enrolled in this study. All subjects were evaluated for laboratory data (ESR, CRP, immunoglobulin G, A and M, complement fragments C3 and C4, LDH, beta2microglobulin, serum levels of rheumatoid factor), autoantibodies (ANA; ENA-SSA, -SSB, -Sm) and lymphocytes subpopulations. For patients, disease activity and damage indexes were assessed with the use of SLEDAI and SLICC and SSDAI and SSDDI for SLE and SS, respectively. BAFF and APRIL were determined by commercial sandwich ELISA kit (R&D Systems, Bender MedSystem). Statistical analysis has been performed with software Prism (Graphpad Instat, version 5.00). Results: APRIL levels were higher among SLE and SS patients compared to controls (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
Italian
تدمد: 0048-7449
2240-2683
Relation: http://www.reumatismo.org/index.php/reuma/article/view/491; https://doaj.org/toc/0048-7449; https://doaj.org/toc/2240-2683
DOI: 10.4081/reumatismo.2010.259
URL الوصول: https://doaj.org/article/c8c748ffc439429ea9cec880a7186e0a
رقم الأكسشن: edsdoj.8c748ffc439429ea9cec880a7186e0a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:00487449
22402683
DOI:10.4081/reumatismo.2010.259