دورية أكاديمية
DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival
| العنوان: | DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival |
|---|---|
| المؤلفون: | J. K. Wiencke, Annette M. Molinaro, Gayathri Warrier, Terri Rice, Jennifer Clarke, Jennie W. Taylor, Margaret Wrensch, Helen Hansen, Lucie McCoy, Emily Tang, Stan J. Tamaki, Courtney M. Tamaki, Emily Nissen, Paige Bracci, Lucas A. Salas, Devin C. Koestler, Brock C. Christensen, Ze Zhang, Karl T. Kelsey |
| المصدر: | Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | Glucocorticoids, such as dexamethasone, are used as anti-inflammatory and immunosuppressive drugs, however patients may exhibit resistance or side effects. Here the authors propose that a dexamethasone related neutrophil-specific DNA methylation index can be used as a marker of glucocorticoid exposure and response and as a prognostic factor in brain tumor survival. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 59906804 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-022-33215-x |
| URL الوصول: | https://doaj.org/article/8c78f67ff3fe480fa4daea5990680400 |
| رقم الأكسشن: | edsdoj.8c78f67ff3fe480fa4daea5990680400 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20411723 59906804 |
|---|---|
| DOI: | 10.1038/s41467-022-33215-x |