دورية أكاديمية
Gene expression pattern after insertion of dexamethasone-eluting electrode into the guinea pig cochlea.
| العنوان: | Gene expression pattern after insertion of dexamethasone-eluting electrode into the guinea pig cochlea. |
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| المؤلفون: | Yutaka Takumi, Shin-ya Nishio, Kenneth Mugridge, Tomohiro Oguchi, Shigenari Hashimoto, Nobuyoshi Suzuki, Satoshi Iwasaki, Claude Jolly, Shin-ichi Usami |
| المصدر: | PLoS ONE, Vol 9, Iss 10, p e110238 (2014) |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | A cochlear implant is an indispensable apparatus for a profound hearing loss patient. But insertion of the electrode entails a great deal of stress to the cochlea, and may cause irreversible damage to hair cells and related nerve structure. Although damage prevention effects of dexamethasone have been reported, long-term administration is difficult. In this study, we used a dexamethasone-eluting electrode in the guinea pig cochlea, and compared the gene expression after 7 days insertion with that of a normal electrode and non-surgically treated control by microarray. 40 genes were up-regulated 2-fold or more in the normal electrode group compared to the non-surgically treated group. Most of the up-regulated genes were associated with immune response and inflammation. In the dexamethasone-eluting group, compared to the normal electrode group, 7 of the 40 genes were further up-regulated, while 12 of them were down-regulated and there was a tendency to return to the non-surgical condition. 9 genes were down-regulated 2-fold or less with normal electrode insertion, and 4 of the 9 tended to return to the non-surgical condition in the dexamethasone-eluting group. These genes are certainly involved in the maintenance of the physiological functions of the cochlea. Our results indicate that the dexamethasone-eluting electrode will have an effect on the normalization of homeostasis in the cochlea. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4203767?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0110238 |
| URL الوصول: | https://doaj.org/article/8ca5d9d7e6da460793ffcc747100758d |
| رقم الأكسشن: | edsdoj.8ca5d9d7e6da460793ffcc747100758d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0110238 |