دورية أكاديمية
Temperature-dependent iron motion in extremophile rubredoxins – no need for ‘corresponding states’
| العنوان: | Temperature-dependent iron motion in extremophile rubredoxins – no need for ‘corresponding states’ |
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| المؤلفون: | Francis E. Jenney, Hongxin Wang, Simon J. George, Jin Xiong, Yisong Guo, Leland B. Gee, Juan José Marizcurrena, Susana Castro-Sowinski, Anna Staskiewicz, Yoshitaka Yoda, Michael Y. Hu, Kenji Tamasaku, Nobumoto Nagasawa, Lei Li, Hiroaki Matsuura, Tzanko Doukov, Stephen P. Cramer |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Rubredoxin, Iron-Sulfur, Extremophile, Hyperthermophile, Psychrophile, Corresponding States, Medicine, Science |
| الوصف: | Abstract Extremophile organisms are known that can metabolize at temperatures down to − 25 °C (psychrophiles) and up to 122 °C (hyperthermophiles). Understanding viability under extreme conditions is relevant for human health, biotechnological applications, and our search for life elsewhere in the universe. Information about the stability and dynamics of proteins under environmental extremes is an important factor in this regard. Here we compare the dynamics of small Fe-S proteins – rubredoxins – from psychrophilic and hyperthermophilic microorganisms, using three different nuclear techniques as well as molecular dynamics calculations to quantify motion at the Fe site. The theory of ‘corresponding states’ posits that homologous proteins from different extremophiles have comparable flexibilities at the optimum growth temperatures of their respective organisms. Although ‘corresponding states’ would predict greater flexibility for rubredoxins that operate at low temperatures, we find that from 4 to 300 K, the dynamics of the Fe sites in these homologous proteins are essentially equivalent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-62261-2 |
| URL الوصول: | https://doaj.org/article/8cf41d96766845649a7740a4dc4b7623 |
| رقم الأكسشن: | edsdoj.8cf41d96766845649a7740a4dc4b7623 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-62261-2 |