ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

التفاصيل البيبلوغرافية
العنوان:	ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
المؤلفون:	Yuan Tian, Bin Yang, Weinan Qiu, Yajing Hao, Zhenxing Zhang, Bo Yang, Nan Li, Shuqun Cheng, Zhangjun Lin, Yao-cheng Rui, Otto K. W. Cheung, Weiqin Yang, William K. K. Wu, Yue-Sun Cheung, Paul B. S. Lai, Jianjun Luo, Joseph J. Y. Sung, Runsheng Chen, Hong-Yang Wang, Alfred S. L. Cheng, Pengyuan Yang
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulation
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-11274-x
URL الوصول:	https://doaj.org/article/a8d1c1e18c374e28bc9f4c1c7dd4b98d
رقم الأكسشن:	edsdoj.8d1c1e18c374e28bc9f4c1c7dd4b98d
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-11274-x