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Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke

التفاصيل البيبلوغرافية
العنوان: Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke
المؤلفون: Medine Cumhur Cure, Ahmet Tufekci, Erkan Cure, Serkan Kirbas, Sabri Ogullar, Aynur Kirbas, Huseyin Unal, Suleyman Yuce, Sevim Cakmak
المصدر: Annals of Indian Academy of Neurology, Vol 16, Iss 4, Pp 498-503 (2013)
بيانات النشر: Wolters Kluwer Medknow Publications, 2013.
سنة النشر: 2013
المجموعة: LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Carotid artery intima-media thickness, ischemic stroke, lipid subfraction, small dense-low-density lipoprotein, tumor necrosis factor-alpha, Neurology. Diseases of the nervous system, RC346-429
الوصف: Objectives: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (a), and nitric oxide (NO) have recently emerged as important stroke risk factors. The aim of the study was to investigate the effects of increased levels of small LDL particle size, TNF-a and NO on the developed ischemic stroke and increased carotid artery intima-media thickness (CIMT). Materials and Methods: A total of 29 women and 25 men (a total of 54 ischemic stroke patients) and a similar age group of 50 controls (29 females and 21 males) were included in the study. CIMT, C-reactive protein (CRP), TNF-a, NO, and lipid subfraction test of the two groups were measured. Results: The mean LDL particle size was smaller in patients with stroke than in the controls (26.8 ± 0.31 nm vs. 27.0 ± 0.31 nm, P = 0.003). sd-LDL, TNF-a, NO, CRP, right CIMT, and left CIMT were higher in patients with stroke than in the controls (respectively; 8.2 ± 7.8 mg/dL vs. 3.3 ± 3.5 mg/dL, P < 0.001;75.6 ± 25.0 pg/mL vs. 65.4 ± 9.1 pg/mL, P = 0.009;76.4 ± 53.3 mmol/L vs. 41.5 ± 27.0 mmol/L, P < 0.001;1.9 ± 2.6 mm vs. 0.4 ± 0.3 mm P < 0.001;0.97 ± 0.38 mm vs. 0.83 ± 0.15 mm, P = 0.007;1.04 ± 0.44 mm vs. 0.87 ± 0.19 mm, P = 0.010). Conclusion: These results show that sd-LDL is independently associated with the incidence of stroke and may be a risk factor in the development of stroke. In addition, TNF-a, NO, right CIMT, and left CIMT may be a risk factor in the development of ischemic stroke.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0972-2327
1998-3549
Relation: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=498;epage=503;aulast=Cure; https://doaj.org/toc/0972-2327; https://doaj.org/toc/1998-3549
DOI: 10.4103/0972-2327.120438
URL الوصول: https://doaj.org/article/8d2a6f8eb4414eb8b8d8720da8bc7534
رقم الأكسشن: edsdoj.8d2a6f8eb4414eb8b8d8720da8bc7534
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09722327
19983549
DOI:10.4103/0972-2327.120438