دورية أكاديمية
PRMT5 promotes chemotherapy‐induced neuroendocrine differentiation in NSCLC
| العنوان: | PRMT5 promotes chemotherapy‐induced neuroendocrine differentiation in NSCLC |
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| المؤلفون: | Qi Shen, Yi Liu, Xuehong Deng, Chang‐Deng Hu |
| المصدر: | Thoracic Cancer, Vol 14, Iss 18, Pp 1764-1773 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | acquired resistance, chemotherapy, NED, neuroendocrine differentiation, PRMT5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background In response to therapeutic treatments, cancer cells can exhibit a variety of resistance phenotypes including neuroendocrine differentiation (NED). NED is a process by which cancer cells can transdifferentiate into neuroendocrine‐like cells in response to treatments, and is now widely accepted as a key mechanism of acquired therapy resistance. Recent clinical evidence has suggested that non‐small cell lung cancer (NSCLC) can also transform into small cell lung cancer (SCLC) in patients treated with EGFR inhibitors. However, whether chemotherapy induces NED to confer therapy resistance in NSCLC remains unknown. Methods We evaluated whether NSCLC cells can undergo NED in response to chemotherapeutic agents etoposide and cisplatin. By Knock‐down of PRMT5 or pharmacological inhibition of PRMT5 to identify its role in the NED process. Results We observed that both etoposide and cisplatin can induce NED in multiple NSCLC cell lines. Mechanistically, we identified protein arginine methyltransferase 5 (PRMT5) as a critical mediator of chemotherapy‐induced NED. Significantly, the knock‐down of PRMT5 or pharmacological inhibition of PRMT5 suppressed the induction of NED and increased the sensitivity to chemotherapy. Conclusion Taken together, our results suggest that targeting PRMT5 may be explored as a chemosensitization approach by inhibiting chemotherapy‐induced NED. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| Relation: | https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714 |
| DOI: | 10.1111/1759-7714.14921 |
| URL الوصول: | https://doaj.org/article/da8d3537b4d74adb9318ad7703e46e36 |
| رقم الأكسشن: | edsdoj.8d3537b4d74adb9318ad7703e46e36 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.14921 |