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Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite‐instable colorectal cancers

التفاصيل البيبلوغرافية
العنوان: Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite‐instable colorectal cancers
المؤلفون: David EFWM vanToledo, Arne GC Bleijenberg, Andrea Venema, Mireille J deWit, Susanne vanEeden, Gerrit A Meijer, Beatrice Carvalho, Evelien Dekker, Peter Henneman, Joep EG IJspeert, Carel JM vanNoesel
المصدر: The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Pathology
مصطلحات موضوعية: colorectal cancer, sessile serrated lesions, serrated neoplasia pathway, methylation, Pathology, RB1-214
الوصف: Abstract Up to 30% of colorectal cancers (CRCs) develop from sessile serrated lesions (SSLs). Within the serrated neoplasia pathway, at least two principally distinct oncogenetic routes exist generating microsatellite‐stable and microsatellite‐instable CRCs, respectively. Aberrant DNA methylation (DNAm) is found early in the serrated pathway and might play a role in both oncogenetic routes. We studied a cohort of 23 SSLs with a small focus (
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2056-4538
Relation: https://doaj.org/toc/2056-4538
DOI: 10.1002/cjp2.348
URL الوصول: https://doaj.org/article/8d41775b841c49d69be4e7043177f8e9
رقم الأكسشن: edsdoj.8d41775b841c49d69be4e7043177f8e9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20564538
DOI:10.1002/cjp2.348