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Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity

التفاصيل البيبلوغرافية
العنوان: Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity
المؤلفون: Hind M. Osman, Tilal Elsaman, Bashir A. Yousef, Esraa Elhadi, Aimun A. E. Ahmed, Eyman Mohamed Eltayib, Malik Suliman Mohamed, Magdi Awadalla Mohamed
المصدر: Journal of Chemistry, Vol 2021 (2021)
بيانات النشر: Hindawi Limited, 2021.
سنة النشر: 2021
المجموعة: LCC:Chemistry
مصطلحات موضوعية: Chemistry, QD1-999
الوصف: Epilepsy is the most common neurological condition and cause of substantial morbidity and mortality. In the present study, the molecular hybridization tool was adopted to obtain six Schiff bases of isatin and adamantane-1-carbohydrazide (18–23). Then, their anticonvulsant activity was evaluated using pentylenetetrazole- (PTZ-) induced seizure model using phenobarbitone as a positive control. Our findings showed that compounds 18–23 provided significant protection against PTZ-induced seizure, and maximum activities were associated with compound 23. Moreover, all investigated compounds increased the latency of induced convulsion and reduced the duration of epilepsy with compound 23 being the best. Interestingly, most of the synthesized molecules showed reduction in neurological symptoms and severity of the seizure. Molecular docking studies suggest GABA-A receptor as a potential target, and in silico ADME screening revealed that the pharmaceutical properties of compound 23 are within the specified limit. Thus, compound 23 was identified as a promising candidate that warrants further drug discovery processes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-9063
2090-9071
Relation: https://doaj.org/toc/2090-9063; https://doaj.org/toc/2090-9071
DOI: 10.1155/2021/6659156
URL الوصول: https://doaj.org/article/8d4216d88e854d8a992717af64e2d67c
رقم الأكسشن: edsdoj.8d4216d88e854d8a992717af64e2d67c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20909063
20909071
DOI:10.1155/2021/6659156