دورية أكاديمية
أعرض في EDS

Expression of calcineurin activity after lung transplantation: a 2-year follow-up.

التفاصيل البيبلوغرافية
العنوان: Expression of calcineurin activity after lung transplantation: a 2-year follow-up.
المؤلفون: Sylvia Sanquer, Catherine Amrein, Dominique Grenet, Romain Guillemain, Bruno Philippe, Veronique Boussaud, Laurence Herry, Celine Lena, Alphonsine Diouf, Michelle Paunet, Eliane M Billaud, Françoise Loriaux, Jean-Philippe Jais, Robert Barouki, Marc Stern
المصدر: PLoS ONE, Vol 8, Iss 3, p e59634 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The objective of this pharmacodynamic study was to longitudinally assess the activity of calcineurin during the first 2 years after lung transplantation. From March 2004 to October 2008, 107 patients were prospectively enrolled and their follow-up was performed until 2009. Calcineurin activity was measured in peripheral blood mononuclear cells. We report that calcineurin activity was linked to both acute and chronic rejection. An optimal activity for calcineurin with two thresholds was defined, and we found that the risk of rejection was higher when the enzyme activity was above the upper threshold of 102 pmol/mg/min or below the lower threshold of 12 pmol/mg/min. In addition, we report that the occurrence of malignancies and viral infections was significantly higher in patients displaying very low levels of calcineurin activity. Taken together, these findings suggest that the measurement of calcineurin activity may provide useful information for the management of the prevention therapy of patients receiving lung transplantation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3607585?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0059634
URL الوصول: https://doaj.org/article/8d54376e5f8c423caf3bd200d05f24f4
رقم الأكسشن: edsdoj.8d54376e5f8c423caf3bd200d05f24f4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0059634