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Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells

التفاصيل البيبلوغرافية
العنوان: Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells
المؤلفون: Jiaqiang Zhao, Lizhi Peng, Wenhua Zheng, Rikang Wang, Lei Zhang, Jian Yang, Heru Chen
المصدر: International Journal of Molecular Sciences, Vol 16, Iss 9, Pp 22795-22810 (2015)
بيانات النشر: MDPI AG, 2015.
سنة النشر: 2015
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: gardenamide A, amantadine, neuroprotection, nNOS, eNOS, NMDA, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Two amantadine (ATD)-gardenamide A (GA) ligands have been designed and synthesized. The bonding of ATD with GA through a methylene carbonyl brigde (L1) enhances the neuroprotective effect against corticosterone (CORT)-induced impairments in PC12 cells; while the bonding through a succinyl brigde (L2) does not. L1 reduces the level of reactive oxygen species (ROS) and cell apoptosis generated by CORT. It restores CORT-changed cell morphology to a state that is closed to normal PC12 cells. One mechanism of L1 to attenuate CORT-induced cell apoptosis is through the adjustment of both caspase-3 and Bcl-2 proteins. Like GA, both nNOS and eNOS might be involved in the neuroprotective mechanism of L1. All the evidences suggest that L1 may be a potential agent to treat depression.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
16092279
Relation: http://www.mdpi.com/1422-0067/16/9/22795; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms160922795
URL الوصول: https://doaj.org/article/8e506e9d701145e09d2151f4d044e67c
رقم الأكسشن: edsdoj.8e506e9d701145e09d2151f4d044e67c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16092279
DOI:10.3390/ijms160922795