دورية أكاديمية
Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations?
| العنوان: | Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? |
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| المؤلفون: | Aaron L. Sarver, Kelly M. Makielski, Taylor A. DePauw, Ashley J. Schulte, Jaime F. Modiano |
| المصدر: | Aging and Cancer, Vol 3, Iss 1, Pp 3-19 (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Geriatrics |
| مصطلحات موضوعية: | cancer‐protective mechanisms, cancer risk, evolution, longevity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Cancer is among the most common causes of death for dogs (and cats) and humans in the developed world, even though it is uncommon in wildlife and other domestic animals. We provide a rationale for this observation based on recent advances in our understanding of the evolutionary basis of cancer. Over the course of evolutionary time, species have acquired and fine‐tuned adaptive cancer‐protective mechanisms that are intrinsically related to their energy demands, reproductive strategies, and expected lifespan. These cancer‐protective mechanisms are general across species and/or specific to each species and their niche, and they do not seem to be limited in diversity. The evolutionarily acquired cancer‐free longevity that defines a species’ life history can explain why the relative cancer risk, rate, and incidence are largely similar across most species in the animal kingdom despite differences in body size and life expectancy. The molecular, cellular, and metabolic events that promote malignant transformation and cancerous growth can overcome these adaptive, species‐specific protective mechanisms in a small proportion of individuals, while independently, some individuals in the population might achieve exceptional longevity. In dogs and humans, recent dramatic alterations in healthcare and social structures have allowed increasing numbers of individuals in both species to far exceed their species‐adapted longevities (by two to four times) without allowing the time necessary for compensatory natural selection. In other words, the cancer‐protective mechanisms that restrain risk at comparable levels to other species for their adapted lifespan are incapable of providing cancer protection over this recent, drastic, and widespread increase in longevity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2643-8909 |
| Relation: | https://doaj.org/toc/2643-8909 |
| DOI: | 10.1002/aac2.12046 |
| URL الوصول: | https://doaj.org/article/c8eaeac0ad9542d5beae4c6db42ceb10 |
| رقم الأكسشن: | edsdoj.8eaeac0ad9542d5beae4c6db42ceb10 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26438909 |
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| DOI: | 10.1002/aac2.12046 |