دورية أكاديمية

Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report

التفاصيل البيبلوغرافية
العنوان: Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report
المؤلفون: Bohn Olga L, de León Eric, Lezama Oscar, Rios-Luna Nina P, Sánchez-Sosa Sergio, Llombart-Bosch Antonio
المصدر: Diagnostic Pathology, Vol 7, Iss 1, p 154 (2012)
بيانات النشر: BMC, 2012.
سنة النشر: 2012
المجموعة: LCC:Pathology
مصطلحات موضوعية: Pulmonary artery, Sarcoma, Angiosarcoma, Immunohistochemistry, Pathology, RB1-214
الوصف: Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. Virtual slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2315906377648045.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1746-1596
Relation: http://www.diagnosticpathology.org/content/7/1/154; https://doaj.org/toc/1746-1596
DOI: 10.1186/1746-1596-7-154
URL الوصول: https://doaj.org/article/8f588c9283034f25bd83036a149b58c6
رقم الأكسشن: edsdoj.8f588c9283034f25bd83036a149b58c6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17461596
DOI:10.1186/1746-1596-7-154