دورية أكاديمية
Meningococcal B Immunisation in Adults and Potential Broader Immunisation Strategies: A Narrative Review
| العنوان: | Meningococcal B Immunisation in Adults and Potential Broader Immunisation Strategies: A Narrative Review |
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| المؤلفون: | George Kassianos, Osamah Barasheed, Victoria Abbing-Karahagopian, Mansour Khalaf, Serdar Ozturk, Angelika Banzhoff, Selim Badur |
| المصدر: | Infectious Diseases and Therapy, Vol 12, Iss 9, Pp 2193-2219 (2023) |
| بيانات النشر: | Adis, Springer Healthcare, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Meningococcal disease, Neisseria meningitidis serogroup B, MenB, Vaccines, 4CMenB, MenB-FHbp, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Recombinant vaccines against invasive meningococcal disease due to Neisseria meningitidis serogroup B (MenB) have shown substantial impact in reducing MenB disease in targeted populations. 4CMenB targets four key N. meningitidis protein antigens; human factor H binding protein (fHbp), Neisserial heparin binding antigen (NHBA), Neisseria adhesin A (NadA) and the porin A protein (PorA P1.4), with one or more of these expressed by most pathogenic MenB strains, while MenB-FHbp targets two distinct fHbp variants. While many countries recommend MenB immunisation in adults considered at high risk due to underlying medical conditions or immunosuppression, there are no recommendations for routine use in the general adult population. We reviewed the burden of MenB in adults, where, while incidence rates remain low (and far lower than in young children 50 years) and key aspects relating to duration of protection remain unclear. Although a broader adult MenB immunisation policy could provide greater protection of the adult population, additional data are required to support policy decision-making. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-8229 2193-6382 |
| Relation: | https://doaj.org/toc/2193-8229; https://doaj.org/toc/2193-6382 |
| DOI: | 10.1007/s40121-023-00836-8 |
| URL الوصول: | https://doaj.org/article/8f7fc635bd144f34931b69271a4c2213 |
| رقم الأكسشن: | edsdoj.8f7fc635bd144f34931b69271a4c2213 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21938229 21936382 |
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| DOI: | 10.1007/s40121-023-00836-8 |