دورية أكاديمية
PHYTOCHEMICAL AND BIOLOGICAL STUDIES OF CONSTITUENTS FROM ROOTS OF Salacia crassifolia (CELASTRACEAE)
| العنوان: | PHYTOCHEMICAL AND BIOLOGICAL STUDIES OF CONSTITUENTS FROM ROOTS OF Salacia crassifolia (CELASTRACEAE) |
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| المؤلفون: | Josana Pereira dos Santos, Willian Xerxes Coelho Oliveira, Sidney A. Vieira-Filho, Rafael C. G. Pereira, Grasiely Faria de Souza, Viviane Alves Gouveia, Adriano de Paula Sabino, Fernanda C. G. Evangelista, Jacqueline Aparecida Takahashi, Marília A. F. Moura, Filipe B. Almeida, Lucienir Pains Duarte |
| المصدر: | Química Nova, Vol 43, Iss 5, Pp 558-567 (2020) |
| بيانات النشر: | Sociedade Brasileira de Química, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | triterpenoids, caryopristimerin, guaianolide, C. elegans, acetylcholinesterase, Chemistry, QD1-999 |
| الوصف: | Salacia crassifolia traditionally known as “Bacupari-do-Cerrado” is used to treat kidney problems, and as a healing agent for coughs and malaria. The phytochemical study of the S. crassifolia roots led to the isolation of thirteen compounds: abruslactone-A (1), urs-12-ene-3β,25,30-triol (2), carioprystimerin (3), β-sitosterol (4), pristimerin (5), dispermoquinone (6), netzahualcoyonol (7), 20-hydroxy-20-epi-tingenone (8), 6-oxo-pristimerol (9), 9β,10β-epoxi-3β-hydroxy-1βH,4βH,5βH,7βH,11αH-guaian-12,8β-olide (10), 3-O-b-D-glucosyl-b-sitosterol (11), 4`-O-methylepigalocatechin (12) and cerebroside (13). The chemical structures of 1-13 were determined by IR, 1D/2D NMR together with X-ray diffractometry. Compounds 2 and 10 are herein described for the first time. Extracts of S. crassifolia and compounds 3, 5, 8 and 9 were evaluated on acetylcholinesterase inhibition, in vitro cytotoxic activity and in vivo toxicity tests using Caenorhabditis elegans model. All tested compounds inhibited acetylcholinesterase, and compounds 3, 8 and 9 demonstrated a greater potential when compared to the standard eserine. The tested compounds showed low cytotoxicity against the THP-1, K562 and MDA-MB-231 cancer cell lines. None of the tested compounds and extracts were toxic against C. elegans since the larvae survival rate in L1 stage was higher than 90%. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 1678-7064 0100-4042 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500558&tlng=en; http://www.scielo.br/pdf/qn/v43n5/0100-4042-qn-43-05-0558.pdf; https://doaj.org/toc/1678-7064 |
| DOI: | 10.21577/0100-4042.20170520 |
| URL الوصول: | https://doaj.org/article/ee8f9d1364a245e3b90adef77959aa53 |
| رقم الأكسشن: | edsdoj.8f9d1364a245e3b90adef77959aa53 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16787064 01004042 |
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| DOI: | 10.21577/0100-4042.20170520 |