دورية أكاديمية
Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations
| العنوان: | Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations |
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| المؤلفون: | Alison H Affinati, Paul V Sabatini, Cadence True, Abigail J Tomlinson, Melissa Kirigiti, Sarah R Lindsley, Chien Li, David P Olson, Paul Kievit, Martin G Myers, Alan C Rupp |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | rhesus macaque, ventromedial hypothalamus, snRNA-seq, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The ventromedial hypothalamic nucleus (VMH) controls diverse behaviors and physiologic functions, suggesting the existence of multiple VMH neural subtypes with distinct functions. Combing translating ribosome affinity purification with RNA-sequencing (TRAP-seq) data with single-nucleus RNA-sequencing (snRNA-seq) data, we identified 24 mouse VMH neuron clusters. Further analysis, including snRNA-seq data from macaque tissue, defined a more tractable VMH parceling scheme consisting of six major genetically and anatomically differentiated VMH neuron classes with good cross-species conservation. In addition to two major ventrolateral classes, we identified three distinct classes of dorsomedial VMH neurons. Consistent with previously suggested unique roles for leptin receptor (Lepr)-expressing VMH neurons, Lepr expression marked a single dorsomedial class. We also identified a class of glutamatergic VMH neurons that resides in the tuberal region, anterolateral to the neuroanatomical core of the VMH. This atlas of conserved VMH neuron populations provides an unbiased starting point for the analysis of VMH circuitry and function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/69065; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.69065 |
| URL الوصول: | https://doaj.org/article/8faf75d4819346d7882986d140a64fa5 |
| رقم الأكسشن: | edsdoj.8faf75d4819346d7882986d140a64fa5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.69065 |