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Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

التفاصيل البيبلوغرافية
العنوان: Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
المؤلفون: Jeannette L Tenthorey, Candice Young, Afeez Sodeinde, Michael Emerman, Harmit S Malik
المصدر: eLife, Vol 9 (2020)
بيانات النشر: eLife Sciences Publications Ltd, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: TRIM5α, retroviral restriction, evolutionary landscape, HIV-1, SIV, N-MLV, Medicine, Science, Biology (General), QH301-705.5
الوصف: Host antiviral proteins engage in evolutionary arms races with viruses, in which both sides rapidly evolve at interaction interfaces to gain or evade immune defense. For example, primate TRIM5α uses its rapidly evolving ‘v1’ loop to bind retroviral capsids, and single mutations in this loop can dramatically improve retroviral restriction. However, it is unknown whether such gains of viral restriction are rare, or if they incur loss of pre-existing function against other viruses. Using deep mutational scanning, we comprehensively measured how single mutations in the TRIM5α v1 loop affect restriction of divergent retroviruses. Unexpectedly, we found that the majority of mutations increase weak antiviral function. Moreover, most random mutations do not disrupt potent viral restriction, even when it is newly acquired via a single adaptive substitution. Our results indicate that TRIM5α’s adaptive landscape is remarkably broad and mutationally resilient, maximizing its chances of success in evolutionary arms races with retroviruses.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/59988; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.59988
URL الوصول: https://doaj.org/article/ee8fb94678b946cc886d87f65964299d
رقم الأكسشن: edsdoj.8fb94678b946cc886d87f65964299d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.59988