دورية أكاديمية
Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
| العنوان: | Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers |
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| المؤلفون: | Ammad Ahmad Farooqi, Ru Wen, Rukset Attar, Simona Taverna, Ghazala Butt, Baojun Xu |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 5, p 2758 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | cancers, berbamine, cell signaling pathways, natural products, TGF/SMAD, delivery, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Natural product research is a cornerstone of the architectural framework of clinical medicine. Berbamine is a natural, potent, pharmacologically active biomolecule isolated from Berberis amurensis. Berbamine has been shown to modulate different oncogenic cell-signaling pathways in different cancers. In this review, we comprehensively analyze how berbamine modulates deregulated pathways (JAK/STAT, CAMKII/c-Myc) in various cancers. We systematically analyze how berbamine induces activation of the TGF/SMAD pathway for the effective inhibition of cancer progression. We also summarize different nanotechnological strategies currently being used for proficient delivery of berbamine to the target sites. Berbamine has also been reported to demonstrate potent anti-cancer and anti-metastatic effects in tumor-bearing mice. The regulation of non-coding RNAs by berbamine is insufficiently studied, and future studies must converge on the identification of target non-coding RNAs. A better understanding of the regulatory role of berbamine in the modulation of non-coding RNAs and cell-signaling pathways will be advantageous in the effective translation of laboratory findings to clinically effective therapeutics. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/5/2758; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23052758 |
| URL الوصول: | https://doaj.org/article/9005e84548ec4f87aac1f54fabd1da84 |
| رقم الأكسشن: | edsdoj.9005e84548ec4f87aac1f54fabd1da84 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23052758 |