Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

التفاصيل البيبلوغرافية
العنوان:	Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
المؤلفون:	Shaoyong Lu, Xinheng He, Zhao Yang, Zongtao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jinpeng Sun, Jian Zhang
المصدر:	Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
بيانات النشر:	Nature Portfolio, 2021.
سنة النشر:	2021
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), and provide insight into its activation mechanism that suggest avenues for the design of allosteric GPCR modulators.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-021-25020-9
URL الوصول:	https://doaj.org/article/ac9008e70a2947a995418dd644c36965
رقم الأكسشن:	edsdoj.9008e70a2947a995418dd644c36965
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-021-25020-9